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Article

Analytical and clinical validation of a blood progranulin ELISA in frontotemporal dementias.

Clinical chemistry and laboratory medicine - 27 Nov 2023

Meda Francisco, Simrén Joel, Borroni Barbara, Cantoni Valentina, Archetti Silvana, Biasiotto Giorgio, Andreasson Ulf, Blennow Kaj, Kvartsberg Hlin, Zetterberg Henrik

Abstract excerpt

OBJECTIVES: Heterozygous mutations in the granulin (GRN) gene may result in haploinsufficiency of progranulin (PGRN), which might lead to frontotemporal dementia (FTD). In this study, we aimed to perform analytical and clinical validation of a commercial progranulin kit for clinical use. METHODS: Analytical validation parameters including assay precision, selectivity, measurement range, dilution linearity,...

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Identifiers

PMID: 37476993
DOI: 10.1515/cclm-2023-0562
PMCID: PMC10598571

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