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Article

Progranulin measurement with a new automated method: a step forward in the diagnostic approach to neurodegenerative disorders.

Clinical chemistry and laboratory medicine - 26 May 2025

Cosma Chiara, Talli Ilaria, Pangrazzi Elisa, Padoan Andrea, Cerutti Helena, Zaninotto Martina, Gabelli Carlo, Plebani Mario

Abstract excerpt

OBJECTIVES: Mutations in the GRN gene encoded glycoprotein progranulin (PGRN), cause 5-10 % of all cases of frontotemporal lobar degeneration (FTLD). The aim of our study was to verify the analytical and clinical performance of an automated chemiluminescent immunoassay method for PGRN measurement recently developed (Chorus Evo, Diesse Diagnostica, Italy). METHODS: Five plasma pools and residual plasma samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39819746
DOI: 10.1515/cclm-2024-1143

Genes

GRN

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