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Article

Role of progranulin as a biomarker for Alzheimer's disease.

Biomarkers in medicine - 1 Feb 2010

Sleegers Kristel, Brouwers Nathalie, Van Broeckhoven Christine

Abstract excerpt

Serum or plasma progranulin (GRN) is a highly accurate of GRN-related frontotemporal lobar degeneration, which is caused by loss-of-function mutations in the GRN gene. Both null mutations and missense mutations in GRN have also been observed in patients with Alzheimer's disease. Here, the evidence for a role of circulating GRN as a biochemical biomarker in neurodegeneration is reviewed, with a specific focus on...

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Source

Identifiers

PMID: 20387302
DOI: 10.2217/bmm.09.82

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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