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Article

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

Gastroenterology - 1 May 2010

Lu Jieli, Herrera Pedro L, Carreira Christine, Bonnavion Rémy, Seigne Christelle, Calender Alain, Bertolino Philippe, Zhang Chang Xian

Abstract excerpt

BACKGROUND & AIMS: The tumor suppressor menin is recognized as a key regulator of pancreatic islet development, proliferation, and beta-cell function, whereas its role in alpha cells remains poorly understood. The purpose of the current study was to address this issue in relation to islet tumor h...

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Source

Identifiers

PMID: 20138042
DOI: 10.1053/j.gastro.2010.01.046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20138042-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.PMID 20138042Read ↗

Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.Semantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localizationSemantic proximity Read ↗

The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulatorsSemantic proximity Read ↗

Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via <i>Pdx1</i> -Directed Inactivation of <i>Men1</i>Semantic proximity Read ↗

Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progressionSemantic proximity Read ↗

<i>glucagon</i> is essential for alpha cell transdifferentiation and beta cell neogenesisSemantic proximity Read ↗

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroupSemantic proximity Read ↗

Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.Semantic proximity Read ↗

The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation.Semantic proximity Read ↗

Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differencesSemantic proximity Read ↗

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