Article
Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
Gastroenterology - 1 May 2010
Lu Jieli, Herrera Pedro L, Carreira Christine, Bonnavion Rémy, Seigne Christelle, Calender Alain, Bertolino Philippe, Zhang Chang Xian
Abstract excerpt
BACKGROUND & AIMS: The tumor suppressor menin is recognized as a key regulator of pancreatic islet development, proliferation, and beta-cell function, whereas its role in alpha cells remains poorly understood. The purpose of the current study was to address this issue in relation to islet tumor histogenesis. METHODS: We generated alpha cell-specific Men1 mutant mice with Cre/loxP technology and carried out...
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