Article
Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.
Endocrinology - 1 Jan 2015
Li Feng, Su Yutong, Cheng Yulong, Jiang Xiuli, Peng Ying, Li Yanli, Lu Jieli, Gu Yanyun, Zhang Changxian, Cao Yanan, Wang Weiqing, Ning Guang
Abstract excerpt
The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon-expressing tumors as well as insulinomas developed in old mutant mice. These glucagon-expressing tumor cells were menin...
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