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Article

Cardiac nuclear receptors: architects of mitochondrial structure and function

12 Feb 2017

Abstract excerpt

The adult heart is uniquely designed and equipped to provide a continuous supply of energy in the form of ATP to support persistent contractile function. This high-capacity energy transduction system is the result of a remarkable surge in mitochondrial biogenesis and maturation during the fetal-to-adult transition in cardiac development. Substantial evidence indicates that nuclear receptor signaling is integral...

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PMID: 28192373
DOI: 10.1172/jci88888

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