Article

Selective activation of intracellular β1AR using a spatially restricted antagonist

2023-11-22

Abstract excerpt

<h4>ABSTRACT</h4> G-protein-coupled receptors (GPCRs) regulate several physiological and pathological processes and represent the target of approximately 30% of FDA-approved drugs. GPCR-mediated signaling was thought to occur exclusively at the plasma membrane. However, recent studies have unveiled their presence and function at subcellular membrane compartments. There is a growing interest in studying compartmen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95f13c6e-bf67-551b-a32a-5f5cc3179954
DOI: 10.1101/2023.11.22.568314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective activation of intracellular β1AR using a spatially restricted antagonistDOI 10.1101/2023.11.22.568314Read

Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling.Semantic proximity Read

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands.Semantic proximity Read

Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Semantic proximity Read

Phosphodiesterase type 1 regulates adenosine 2A receptor-associated cAMP signaling at the plasma membrane to increase myocardial contractilitySemantic proximity Read

Characterization of the residues in helix 8 of the human beta1-adrenergic receptor that are involved in coupling the receptor to G proteins.Semantic proximity Read

Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.Semantic proximity Read

Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist.Semantic proximity Read

Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes.Semantic proximity Read

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes.Semantic proximity Read

Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase.Semantic proximity Read

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.Semantic proximity Read

Off-target-free chemogenetic platform that decodes physiological roles of target GPCRsSemantic proximity Read