Article
SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation.
Developmental cell - 13 Dec 2011
Tan Mingjia, Zhao Yongchao, Kim Sun-Jung, Liu Margaret, Jia Lijun, Saunders Thomas L, Zhu Yuan, Sun Yi
Abstract excerpt
SAG/RBX2/ROC2 protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1 (NF1). Mice mutant for Sag died at embryonic day 11.5-12.5 with severe abnormalities in vascular and nervous system....
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