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A negative feedback loop between XBP1 and Fbw7 regulates cancer development

19 Feb 2019

Abstract excerpt

In cancer, activation of X-box binding protein (XBP1) has a critical role in tumorigenesis and cancer progression. Transcriptional regulatory mechanism of XBP1 in cancer development has been well known, however, regulation of ubiquitination and degradation of XBP1 has not been elucidated yet. Here we show that Fbw7, a substrate recognition component of the SKP1-Cullin-F-box-type E3 ligase, interacts with XBP1 in...

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PMID: 30783083
DOI: 10.1038/s41389-019-0124-4

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