Article
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.
The Journal of clinical investigation - 1 Feb 2014
Li Hua, Tan Mingjia, Jia Lijun, Wei Dongping, Zhao Yongchao, Chen Guoan, Xu Jie, Zhao Lili, Thomas Dafydd, Beer David G, Sun Yi
Abstract excerpt
Cullin-RING ligases (CRLs) are a family of E3 ubiquitin ligase complexes that rely on either RING-box 1 (RBX1) or sensitive to apoptosis gene (SAG), also known as RBX2, for activity. RBX1 and SAG are both overexpressed in human lung cancer; however, their contribution to patient survival and lung tumorigenesis is unknown. Here, we report that overexpression of SAG, but not RBX1, correlates with poor patient...
Topics
- Animals
- Cell Line, Tumor
- Cell Survival
- Cell Transformation, Neoplastic
- Female
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Genotype
- Humans
- Lung Neoplasms
- Male
- Mice
- Mutation