Article
Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.
The European respiratory journal - 1 Aug 2016
Osei Emmanuel T, Noordhoek Jacobien A, Hackett Tillie L, Spanjer Anita I R, Postma Dirkje S, Timens Wim, Brandsma Corry-Anke, Heijink Irene H
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) has been associated with aberrant epithelial-mesenchymal interactions resulting in inflammatory and remodelling processes. We developed a co-culture model using COPD and control-derived airway epithelial cells (AECs) and lung fibroblasts to understand the mediators that are involved in remodelling and inflammation in COPD.AECs and fibroblasts obtained from COPD and...
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