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Article

Fibroblasts that resist cigarette smoke-induced senescence acquire profibrotic phenotypes.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2014

Kanaji Nobuhiro, Basma Hesham, Nelson Amy, Farid Maha, Sato Tadashi, Nakanishi Masanori, Wang Xingqi, Michalski Joel, Li YingJi, Gunji Yoko, Feghali-Bostwick Carol, Liu Xiangde, Rennard Stephen I

Abstract excerpt

This study assessed the effect of extended exposure to cigarette smoke extract (CSE) on tissue repair functions in lung fibroblasts. Human fetal (HFL-1) and adult lung fibroblasts were exposed to CSE for 14 days. Senescence-associated β-galactosidase (SA β-gal) expression, cell proliferation, and tissue repair functions including chemotaxis and gel contraction were assessed. HFL-1 proliferation was inhibited by...

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Identifiers

PMID: 25015975
DOI: 10.1152/ajplung.00041.2014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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