Article
Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts.
Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2011
Ramírez Gustavo, Hagood James S, Sanders Yan, Ramírez Remedios, Becerril Carina, Segura Lourdes, Barrera Lourdes, Selman Moisés, Pardo Annie
Abstract excerpt
Fibroblasts differ in a variety of phenotypic features, including the expression of Thy-1 a glycophosphatidylinositol-linked glycoprotein. Fibroblasts in idiopathic pulmonary fibrosis (IPF) are Thy-1 negative, whereas most fibroblasts from normal lungs are Thy-1 positive. However, the functional consequences of the absence of Thy-1 are not fully understood. We analyzed the expression of Thy-1 in several primary...
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