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Article

Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.

Blood - 19 Jan 2012

Jen Kuang-Yu, Song Ihn Young, Banta Karl Luke, Wu Di, Mao Jian-Hua, Balmain Allan

Abstract excerpt

T-cell acute lymphoblastic lymphomas commonly demonstrate activating Notch1 mutations as well as mutations or deletions in Fbxw7. However, because Fbxw7 targets Notch1 for degradation, genetic alterations in these genes are expected to be mutually exclusive events in lymphomagenesis. Previously, by using a radiation-induced Tp53-deficient mouse model for T-cell acute lymphoblastic lymphoma, we reported that loss...

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Source

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Identifiers

PMID: 22117044
DOI: 10.1182/blood-2011-01-327619
PMCID: PMC3265203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.PMID 22117044Read ↗

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Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas.Semantic proximity Read ↗

Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.Semantic proximity Read ↗

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