Article
Activating Notch1 mutations in mouse models of T-ALL.
Blood - 15 Jan 2006
O'Neil Jennifer, Calvo Jennifer, McKenna Keith, Krishnamoorthy Veena, Aster Jon C, Bassing Craig H, Alt Frederick W, Kelliher Michelle, Look A Thomas
Abstract excerpt
Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. We sought to determine whether these mutations are also acquired in mouse models of T-ALL. We sequenced the heterodimerization domain and the PEST domain of Notch1 in our mouse model of TAL1-induced leukemia and found that 74% of the tumors harbor activating mutations in Notch1....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.