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Article

Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2010

Panchanathan Ravichandran, Duan Xin, Shen Hui, Rathinam Vijay A K, Erickson Loren D, Fitzgerald Katherine A, Choubey Divaker

Abstract excerpt

Murine Aim2 and p202 proteins (encoded by the Aim2 and Ifi202 genes) are members of the IFN-inducible p200 protein family. Both proteins can sense dsDNA in the cytoplasm. However, upon sensing dsDNA, only the Aim2 protein through its pyrin domain can form an inflammasome to activate caspase-1 and induce cell death. Given that the p202 protein has been predicted to inhibit the activation of caspase-1 by the Aim2...

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Identifiers

PMID: 21057088
DOI: 10.4049/jimmunol.1002468
PMCID: PMC3059233

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STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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