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Article

Genetic variants of NBS1 predict clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer in Chinese.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Xu Jia-Li, Hu Ling-Min, Huang Ming-De, Zhao Wan, Yin Yong-Mei, Hu Zhi-Bin, Ma Hong-Xia, Shen Hong-Bing, Shu Yong-Qian

Abstract excerpt

OBJECTIVE: NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate the effect of two critical polymorphisms (rs1805794 and rs13312840) in NBS1 on treatment response and prognosis of advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy. METHODS: Using TaqMan methods, we genotyped the two polymorphisms in 147 NSCLC patients. Odds...

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PMID: 22631660
DOI: 10.7314/apjcp.2012.13.3.851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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