Article
Characterization of CagI in the cag pathogenicity island of Helicobacter pylori.
Current microbiology - 1 Feb 2012
Wang Hua, Han Jun, Chen Deyu, Duan Xiujie, Gao Xiaohuan, Wang Xiaochun, Shao Shihe
Abstract excerpt
Helicobacter pylori is a highly successful human-specific gastric pathogen that infects up to 50% of the world's population. Virulent H. pylori isolates harbor the cytotoxin-associated genes pathogenicity island (cag-PAI), which encodes a type IV secretion system that translocates bacterial effector (e.g., CagA oncoprotein) molecules into host cells. Although some cag-PAI genes are shown to be required for CagA...
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