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Analyses of the cag pathogenicity island of Helicobacter pylori

1 Apr 1998

Abstract excerpt

Most strains of Helicobacter pylori from patients with peptic ulcer disease or intestinal-type gastric cancer carry cagA, a gene that encodes an immunodominant protein of unknown function, whereas many of the strains from asymptomatically infected persons lack this gene. Recent studies showed that the cagA gene lies near the right end of a approximately 37kb DNA segment (a pathogenicity island, or PAI) that is...

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PMID: 9593295
DOI: 10.1046/j.1365-2958.1998.00770.x

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