<i>cag</i> , a pathogenicity island of <i>Helicobacter pylori,</i> encodes type I-specific and disease-associated virulence factors

Abstract excerpt

cagA, a gene that codes for an immunodominant antigen, is present only in Helicobacter pylori strains that are associated with severe forms of gastroduodenal disease (type I strains). We found that the genetic locus that contains cagA (cag) is part of a 40-kb DNA insertion that likely was acquired horizontally and integrated into the chromosomal glutamate racemase gene. This pathogenicity island is flanked by...

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