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Interaction with CagF Is Required for Translocation of CagA into the Host via the<i>Helicobacter pylori</i>Type IV Secretion System

20 Dec 2005

Abstract excerpt

Development of severe gastric diseases is strongly associated with those strains of Helicobacter pylori that contain the cag pathogenicity island (PAI) inserted into the chromosome. The cag PAI encodes a type IV secretion system that translocates the major disease-associated virulence protein, CagA, into the host epithelial cell. CagA then affects host signaling pathways, leading to cell elongations and...

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PMID: 16368981
DOI: 10.1128/iai.74.1.273-281.2006

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Interaction with CagF Is Required for Translocation of CagA into the Host via the<i>Helicobacter pylori</i>Type IV Secretion SystemPMID 16368981Read ↗

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