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Inhibitors of Helicobacter pylori ATPase Cagα block CagA transport and cag virulence

27 Sept 2006

Abstract excerpt

With the steadily increasing occurrence of antibiotic resistance in bacteria, there is a great need for new antibacterial compounds. The approach described here involves targeting virulence-related bacterial type IV secretion systems (TFSSs) with small-molecule inhibitors. The cag TFSS of Helicobacter pylori was chosen as a model, and novel inhibitors directed against the cag VirB11-type ATPase Cagalpha were...

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PMID: 17005973
DOI: 10.1099/mic.0.28984-0

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