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Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2012

Asuri Prashanth, Bartel Melissa A, Vazin Tandis, Jang Jae-Hyung, Wong Tiffany B, Schaffer David V

Abstract excerpt

Efficient approaches for the precise genetic engineering of human pluripotent stem cells (hPSCs) can enhance both basic and applied stem cell research. Adeno- associated virus (AAV) vectors are of particular interest for their capacity to mediate efficient gene delivery to and gene targeting in various cells. However, natural AAV serotypes offer only modest transduction of human embryonic and induced pluripotent...

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Identifiers

PMID: 22108859
DOI: 10.1038/mt.2011.255
PMCID: PMC3277219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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