Article

Genome-scale analysis of cellular restriction factors that inhibit transgene expression from adeno-associated virus vectors

2022-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated virus (AAV) vectors are one of the leading platforms for gene delivery for the treatment of human genetic diseases, but the antiviral cellular mechanisms that interfere with optimal transgene expression are incompletely understood. Here, we performed two genome-scale CRISPR screens to identify cellular factors that restrict transgene expression from recombinant AAV vectors. Our...

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Literature Corpus work: 7c0bca14-d925-53b4-8d72-5502f5508cfb
DOI: 10.1101/2022.07.13.499963

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