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Article

Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2011

Lei Yuning, Lee Chi-Lin, Joo Kye-Il, Zarzar Jonathan, Liu Yarong, Dai Bingbing, Fox Victoria, Wang Pin

Abstract excerpt

Human embryonic stem (hES) cells are renewable cell sources that have potential applications in regenerative medicine. The development of technologies to produce permanent and site-specific genome modifications is in demand to achieve future medical implementation of hES cells. We report herein that a baculoviral vector (BV) system carrying zinc-finger nucleases (ZFNs) can successfully modify the hES cell genome....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21326219
DOI: 10.1038/mt.2011.12
PMCID: PMC3098635

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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