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Article

Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.

Journal of leukocyte biology - 1 Apr 2014

Ostrovsky Olga, Shimoni Avichai, Baryakh Polina, Morgulis Yan, Mayorov Margarita, Beider Katia, Shteingauz Anna, Ilan Neta, Vlodavsky Israel, Nagler Arnon

Abstract excerpt

Heparanase is an endo-β-glucuronidase that specifically cleaves the saccharide chains of HSPGs, important structural and functional components of the ECM. Cleavage of HS leads to loss of the structural integrity of the ECM and release of HS-bound cytokines, chemokines, and bioactive angiogenic- a...

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Share to Glucuronidase
Share to Graft vs Host Disease
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Lipopolysaccharides

Share to Toll-Like Receptor 4

Share to Transplantation Conditioning

Share to Transplantation, Homologous

Source

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Identifiers

PMID: 24319286
DOI: 10.1189/jlb.0313147
PMCID: PMC4046248

Genes

HPSE
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24319286-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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