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Article

TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome.

The Journal of clinical investigation - 1 Dec 2004

Ng Connie M, Cheng Alan, Myers Loretha A, Martinez-Murillo Francisco, Jie Chunfa, Bedja Djahida, Gabrielson Kathleen L, Hausladen Jennifer M W, Mecham Robert P, Judge Daniel P, Dietz Harry C

Abstract excerpt

Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the pathogenesis of this condition. MVP can occur in the context of genetic syndromes, including Marfan syndrome (MFS), an autosomal-dominant connective tissue disorder caused by mutations in fibrillin-1. Fibrillin...

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Source

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Identifiers

PMID: 15546004
DOI: 10.1172/JCI22715
PMCID: PMC529498

Genes

MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15546004-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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