Article
The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
Biotechnology and applied biochemistry - 1 Oct 2022
Mahmood Nasir, Bhatti Sadia, Abbas Shahzada Nadeem, Shahid Saman, Nasir Sarah Bushra
Abstract excerpt
The pncA gene encodes pyrazinamidase enzyme which converts drug pyrazinamide to active form pyrazinoic acid, but mutations in this gene can prevent enzyme activity which leads to pyrazinamide resistance. The cross-sectional study was carried out during 2016-2017 for 12 months. The purpose of the study was to detect mutation at codon 12 and codon 85 in the pncA gene in local multidrug-resistant tuberculosis...
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