Article
HLA class II sequences and genetic susceptibility to insulin dependent diabetes mellitus.
Bailliere's clinical endocrinology and metabolism - 1 Sept 1991
Erlich H A
Abstract excerpt
The analysis of HLA class II sequence variation in IDDM patients and controls, made possible by the PCR, has revealed that specific alleles are associated with IDDM. The HLA-DQ beta chain appears to play a role in determining genetic susceptibility and resistance, although polymorphisms in the DRB1, the DQ alpha, and the DP beta chain may also contribute. Although there is a correlation between susceptibility and...
Topics
- Amino Acid Sequence
- Base Sequence
- Diabetes Mellitus, Type 1
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DP Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Molecular Sequence Data