Article
Epidermal wound repair is regulated by the planar cell polarity signaling pathway.
Developmental cell - 20 Jul 2010
Caddy Jacinta, Wilanowski Tomasz, Darido Charbel, Dworkin Sebastian, Ting Stephen B, Zhao Quan, Rank Gerhard, Auden Alana, Srivastava Seema, Papenfuss Tony A, Murdoch Jennifer N, Humbert Patrick O, Parekh Vishwas, Boulos Nidal, Weber Thomas, Zuo Jian, Cunningham John M, Jane Stephen M
Abstract excerpt
The mammalian PCP pathway regulates diverse developmental processes requiring coordinated cellular movement, including neural tube closure and cochlear stereociliary orientation. Here, we show that epidermal wound repair is regulated by PCP signaling. Mice carrying mutant alleles of PCP genes Vangl2, Celsr1, PTK7, and Scrb1, and the transcription factor Grhl3, interact genetically, exhibiting failed wound...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.