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Article

Grainyhead-like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression.

Cancer medicine - 1 Nov 2017

Nishino Hitoe, Takano Shigetsugu, Yoshitomi Hideyuki, Suzuki Kensuke, Kagawa Shingo, Shimazaki Reiri, Shimizu Hiroaki, Furukawa Katsunori, Miyazaki Masaru, Ohtsuka Masayuki

Abstract excerpt

The epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) contribute to cancer metastasis of pancreatic ductal adenocarcinoma (PDAC). We explored the role of grainyhead-like 2 (GRHL2), a suppressor of EMT, in the progression of PDAC. Expressions of GRHL2 were assessed using surgically resected PDAC tissues by immunohistochemistry analysis, and in vitro using human and mouse PDAC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28960866
DOI: 10.1002/cam4.1212
PMCID: PMC5673909

Genes

GRHL2
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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