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Article

Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells.

Carcinogenesis - 1 Dec 2007

Cheung Ronald S Y, Brooling John T, Johnson Melissa M, Riehle Kimberly J, Campbell Jean S, Fausto Nelson

Abstract excerpt

The MYC oncogene induces both cell proliferation and apoptosis. The apoptotic function of MYC is thought to inhibit carcinogenesis; thus, when disrupted, tumorigenic potential is increased. Both MYC and transforming growth factor alpha (TGFalpha) are commonly over-expressed in hepatocellular carcinomas, and transgenic mice expressing these genes rapidly develop tumors via the suppression of MYC-induced apoptosis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Liver Neoplasms

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Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 17698969
DOI: 10.1093/carcin/bgm184

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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