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Article

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.

Journal of neuropathology and experimental neurology - 1 May 2009

McFarland Nikolaus R, Fan Zhanyun, Xu Kui, Schwarzschild Michael A, Feany Mel B, Hyman Bradley T, McLean Pamela J

Abstract excerpt

Lewy bodies are found in Parkinson disease and related disorders and are extensively phosphorylated at Ser-129 (S129), but whether S129 phosphorylation mediates alpha-synuclein aggregation and neurotoxicity has been controversial. We used recombinant adeno-associated virus to overexpress alpha-synuclein in the rat nigrostriatal system. Rats were injected with recombinant adeno-associated virus 2/8 expressing...

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Identifiers

PMID: 19525899
DOI: 10.1097/NEN.0b013e3181a24b53
PMCID: PMC2753269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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