Article
Interaction between filaggrin null mutations and tobacco smoking in relation to asthma.
The Journal of allergy and clinical immunology - 1 Feb 2012
Berg Nikolaj Drimer, Husemoen Lise Lotte N, Thuesen Betina Heinsbæk, Hersoug Lars-Georg, Elberling Jesper, Thyssen Jacob Pontoppidan, Carlsen Berit Christina, Johansen Jeanne Duus, Menné Torkil, Bønnelykke Klaus, Stender Steen, Meldgaard Michael, Szecsi Pal Bela, Linneberg Allan
Abstract excerpt
BACKGROUND: The mechanisms underlying the association between filaggrin (FLG) deficiency and asthma are not known. It has been hypothesized that FLG deficiency leads to enhanced percutaneous exposure to environmental substances that might trigger immune responses. We hypothesized that interactions between FLG deficiency and environmental exposures play a role in asthma development. OBJECTIVE: We sought to...
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