Article
The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population.
The British journal of dermatology - 1 Jun 2010
Thyssen J P, Johansen J D, Linneberg A, Menné T, Nielsen N H, Meldgaard M, Szecsi P B, Stender S, Carlsen B C
Abstract excerpt
BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin...
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