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Article

Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque.

PloS one - 1 Jan 2011

Dong Chuanhui, Della-Morte David, Wang Liyong, Cabral Digna, Beecham Ashley, McClendon Mark S, Luca Corneliu C, Blanton Susan H, Sacco Ralph L, Rundek Tatjana

Abstract excerpt

OBJECTIVE: Sirtuins (SIRTs) and mitochondrial uncoupling proteins (UCPs) have been implicated in cardiovascular diseases through the control of reactive oxygen species production. This study sought to investigate the association between genetic variants in the SIRT and UCP genes and carotid plaque. METHODS: In a group of 1018 stroke-free subjects from the Northern Manhattan Study with high-definition carotid...

Read the complete abstract on PubMed

Topics

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Share to Carotid Artery Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

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Share to Plaque, Atherosclerotic

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Source

Open in PubMed Open full text

Identifiers

PMID: 22087257
DOI: 10.1371/journal.pone.0027157
PMCID: PMC3210138

Genes

SIRT6
SIRT5
UCP1
SIRT1
SIRT3
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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