Article
Familial aggregation and genome-wide linkage analysis of carotid artery plaque: the NHLBI family heart study.
Human heredity - 1 Jan 2004
Pankow James S, Heiss Gerardo, Evans Gregory W, Sholinsky Phyliss, Province Michael A, Coon Hilary, Ellison R Curtis, Miller Michael B, Qaqish Bahjat
Abstract excerpt
OBJECTIVE: To evaluate familial and genetic influences on carotid artery plaque, a qualitative marker of the systemic burden of atherosclerosis. METHODS: The design was a cross-sectional study of 2,223 members of 525 randomly-ascertained families and 2,514 members of 589 high coronary heart disease (CHD) risk families from 4 U.S. communities. RESULTS: The prevalence of plaque was 33, 36, and 47%, respectively,...
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