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Article

Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2005

Oberkofler H, Iglseder B, Klein K, Unger J, Haltmayer M, Krempler F, Paulweber B, Patsch W

Abstract excerpt

OBJECTIVE: Reactive oxygen species (ROS) contribute to atherogenesis. Uncoupling protein 2 (UCP2) reduces mitochondrial ROS generation and protects against the disease in animal models. A common -866G/A promoter polymorphism that has been associated with obesity and beta-cell function may also affect UCP2 gene expression in cells of the arterial wall. METHODS AND RESULTS: Genotype distributions of the -866G/A and...

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Source

Identifiers

PMID: 15604415
DOI: 10.1161/01.ATV.0000153141.42033.22

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women.PMID 15604415Read ↗

Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.Semantic proximity Read ↗

The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men.Semantic proximity Read ↗

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

The common -866G/A polymorphism of the UCP2 gene in healthy Iranians compared with world populations.Semantic proximity Read ↗

Uncoupling protein 2 -866G/A and uncoupling protein 3 -55C/T polymorphisms in young South African Indian coronary artery disease patients.Semantic proximity Read ↗

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic healthSemantic proximity Read ↗

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.Semantic proximity Read ↗

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.Semantic proximity Read ↗

Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes.Semantic proximity Read ↗

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.Semantic proximity Read ↗

Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study.Semantic proximity Read ↗

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.Semantic proximity Read ↗

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