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Article

Competition for cofactor-dependent DNA binding underlies Hox phenotypic suppression.

Genes & development - 15 Nov 2011

Noro Barbara, Lelli Katherine, Sun Liping, Mann Richard S

Abstract excerpt

Hox transcription factors exhibit an evolutionarily conserved functional hierarchy, termed phenotypic suppression, in which the activity of posterior Hox proteins dominates over more anterior Hox proteins. Using directly regulated Hox targeted reporter genes in Drosophila, we show that posterior Hox proteins suppress the activities of anterior ones by competing for cofactor-dependent DNA binding. Furthermore, we...

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Identifiers

PMID: 22085961
DOI: 10.1101/gad.175539.111
PMCID: PMC3222899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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