Article
Insights into Hox protein function from a large scale combinatorial analysis of protein domains.
PLoS genetics - 1 Oct 2011
Merabet Samir, Litim-Mecheri Isma, Karlsson Daniel, Dixit Richa, Saadaoui Mehdi, Monier Bruno, Brun Christine, Thor Stefan, Vijayraghavan K, Perrin Laurent, Pradel Jacques, Graba Yacine
Abstract excerpt
Protein function is encoded within protein sequence and protein domains. However, how protein domains cooperate within a protein to modulate overall activity and how this impacts functional diversification at the molecular and organism levels remains largely unaddressed. Focusing on three domains of the central class Drosophila Hox transcription factor AbdominalA (AbdA), we used combinatorial domain mutations and...
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