Article
Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2005
Lebrecht Danielle, Foehr Marisa, Smith Eric, Lopes Francisco J P, Vanario-Alonso Carlos E, Reinitz John, Burz David S, Hanes Steven D
Abstract excerpt
Cooperative interactions by DNA-binding proteins have been implicated in cell-fate decisions in a variety of organisms. To date, however, there are few examples in which the importance of such interactions has been explicitly tested in vivo. Here, we tested the importance of cooperative DNA binding by the Bicoid protein in establishing a pattern along the anterior-posterior axis of the early Drosophila embryo. We...
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