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Article

Suboptimal Intermediates Underlie Evolution of the Bicoid Homeodomain.

Molecular biology and evolution - 19 May 2021

Onal Pinar, Gunasinghe Himari Imaya, Umezawa Kristaley Yui, Zheng Michael, Ling Jia, Azeez Leen, Dalmeus Anecine, Tazin Tasmima, Small Stephen

Abstract excerpt

Changes in regulatory networks generate materials for evolution to create phenotypic diversity. For transcription networks, multiple studies have shown that alterations in binding sites of cis-regulatory elements correlate well with the gain or loss of specific features of the body plan. Less is known about alterations in the amino acid sequences of the transcription factors (TFs) that bind these elements. Here...

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Identifiers

PMID: 33599280
DOI: 10.1093/molbev/msab051
PMCID: PMC8136501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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