Article
Functional specificity of a Hox protein mediated by the recognition of minor groove structure.
Cell - 2 Nov 2007
Joshi Rohit, Passner Jonathan M, Rohs Remo, Jain Rinku, Sosinsky Alona, Crickmore Michael A, Jacob Vinitha, Aggarwal Aneel K, Honig Barry, Mann Richard S
Abstract excerpt
The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly understood step in the control of gene expression. Members of the Hox family of transcription factors bind DNA by making nearly identical major groove contacts via the recognition helices of their homeodomains. In vivo specificity, however, often depends on extended and unstructured regions that link Hox homeodomains...
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