Article
Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites.
Development (Cambridge, England) - 1 Jul 2002
Galant Ron, Walsh Christopher M, Carroll Sean B
Abstract excerpt
Homeotic (Hox) genes regulate the identity of structures along the anterior-posterior axis of most animals. The low DNA-binding specificities of Hox proteins have raised the question of how these transcription factors selectively regulate target gene expression. The discovery that the Extradenticle (Exd)/Pbx and Homothorax (Hth)/Meis proteins act as cofactors for several Hox proteins has advanced the view that...
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