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Article

Evolutionary dynamics of feedback escape and the development of stem-cell-driven cancers.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2011

Rodriguez-Brenes Ignacio A, Komarova Natalia L, Wodarz Dominik

Abstract excerpt

Cancers are thought to arise in tissue stem cells, and similar to healthy tissue, are thought to be maintained by a small population of tumor stem or initiating cells, whereas the majority of tumor cells are more differentiated with limited replicative potential. Healthy tissue homeostasis is achieved by feedback loops, and particular importance has been attached to signals secreted from differentiated cells that...

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Identifiers

PMID: 22084071
DOI: 10.1073/pnas.1107621108
PMCID: PMC3223454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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