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Formation of benign tumors by stem cell deregulation

27 Oct 2022

Abstract excerpt

Within living organisms, stem cells respond to various cues, including to niche signals and growth factors. Niche signals originate from the stem cell's microenvironment and promote the undifferentiated state by preventing differentiation, allowing for stem cell self-renewal. On the other hand, growth factors promote stem cell growth and proliferation, while their sources comprise of a systemic input reflecting...

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PMID: 36301803
DOI: 10.1371/journal.pgen.1010434

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