Article

Adaptive Cancer Suppression among Tissues through Reduced Stem Cell Mutation Rates

2026-04-16

Abstract excerpt

Since most cancers are initiated by driver mutations arising in somatic cells, the risk of cancer should be explained by the probability of driver mutations as a function of the product of the number of stem cells and the stem cell division rate for a tissue. However, such models of driver-mutation initiated carcinogenesis fail to adequately predict cancer risk. It has been suggested that the missing component is...

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Literature Corpus work: ab0c1f57-e36a-5c6d-b3a0-752423d9eabb
DOI: 10.64898/2026.04.13.718347

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