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Article

Genome shuffling enhanced ε-poly-L-lysine production by improving glucose tolerance of Streptomyces graminearus.

Applied biochemistry and biotechnology - 1 Jan 2012

Li Shu, Li Feng, Chen Xu-Sheng, Wang Liang, Xu Jian, Tang Lei, Mao Zhong-Gui

Abstract excerpt

The productivity of ε-poly-L: -lysine (ε-PL) in currently reported wild-type strains is low. Here we improved glucose tolerance of a Streptomyces graminearus strain LS-B1 by genome shuffling while simultaneously enhancing the ε-PL productivity. The starting population was generated by ultraviolet irradiation and nitrosoguanidine mutagenesis and then subjected for recursive protoplast fusion. The positive colonies...

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PMID: 22083395
DOI: 10.1007/s12010-011-9437-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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