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Article

Predicting phenotypic variation in yeast from individual genome sequences.

Nature genetics - 13 Nov 2011

Jelier Rob, Semple Jennifer I, Garcia-Verdugo Rosa, Lehner Ben

Abstract excerpt

A central challenge in genetics is to predict phenotypic variation from individual genome sequences. Here we construct and evaluate phenotypic predictions for 19 strains of Saccharomyces cerevisiae. We use conservation-based methods to predict the impact of protein-coding variation within genes on protein function. We then rank strains using a prediction score that measures the total sum of function-altering...

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PMID: 22081227
DOI: 10.1038/ng.1007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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