Article
Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group.
Nucleic acids research - 1 Mar 2012
Petrova Natalya S, Chernikov Ivan V, Meschaninova Mariya I, Dovydenko Iiya S, Venyaminova Aliya G, Zenkova Marina A, Vlassov Valentin V, Chernolovskaya Elena L
Abstract excerpt
The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the carrier-free cellular uptake of nuclease-resistant anti-MDR1 siRNA equipped with lipophilic residues (cholesterol, lithocholic acid, oleyl alcohol and litocholic acid oleylamide) attached to the 5'-end of the sense strand via...
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